This study was a large collaboration between labs at UC Davis, Kansas University, University of Colorado and Washington University in St Louis. The project discovered that arginine auxotrophy is a key feature of autosomal dominant polycystic kidney disease (ADPKD). The results suggest that dietary arginine depletion, or targeting of the arginine metabolic pathway, may be a new therapeutic avenue in patients with ADPKD.
The research article titled “Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis” was published in AJP-Renal Physiology and can be found here.
The accompanying Research Highlight titled “Arginine auxotrophy in PKD” was published in Nature Reviews – Nephrology and can be found here.