Our collaboration on the role of Cep120 in  axon development is published in Cell Reports

Our collaboration on the role of Cep120 in  axon development is published in Cell Reports
Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon. How these modifications are spatially coordinated is unclear. Here, via high-resolution microscopy, we show that early developing neurons have fewer somatic acetylated MTs restricted near the centrosome. At later stages, however, acetylated MTs spread out in soma and concentrate in growing […]

Welcome to our new research assistant Chidera Agwu!

Welcome to our new research assistant Chidera Agwu!
Chidera did his undergraduate studies at  Saint Louis University (MO), receiving his Bachelor of Science degree in Neuroscience. He will be investigating how defects in centrosome biogenesis and structure affect embryonic kidney development. Welcome to the lab!

Welcome to our new graduate rotation student DeHaven McCrary!

Welcome to our new graduate rotation student DeHaven McCrary!
DeHaven did his undergraduate studies at  Westminster College (MO). He then completed a Master of Science degree in Physiological Sciences at the University of Arizona, where he studied the role of microtubule associated proteins in GLUT4 translocation during insulin stimulation . He will be investigating microtubule dynamics and reorganization during stem cell differentiation. Welcome to the lab!

Welcome our new postdoc Dr. Maneesha Pandey!

Welcome our new postdoc Dr. Maneesha Pandey!
Maneesha did her graduate studies with Dr. Cynthia He at the National University of Singapore. She studied the role of an arginine kinase and the lipidated protein intraflagellar transport (LIFT) pathway in cilia of Trypanosoma brucei. She will be studying cellular pathways that regulate centrosome-cilia protein trafficking. Welcome to the lab!

We’re recruiting – multiple positions available.

We’re recruiting – multiple positions available.
We are looking for postdoctoral fellows, graduate students and research assistants interested in the biology of microtubules, centrosomes and cilia. Our lab investigates how mutations in centrosomal and ciliary genes disrupt normal cell physiology, leading to human disease syndromes called “Ciliopathies”. These include cystic-fibrotic kidney diseases, and respiratory/airway defects such as Primary Cilia Dyskinesia. Multiple […]

The lab is awarded a 3-year grant from the Department of Defense!

The lab is awarded a 3-year grant from the Department of Defense!
The Mahjoub lab has received a 3-year, $1.83M Investigator-Initiated Research Award from the Department of Defense – Congressionally Directed Medical Research Program. The project is titled “Targeting Centrosome Clustering as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease“.  This project focuses on the preclinical evaluation of small molecule inhibitors that target centrosome clustering as a […]

Our NHLBI grant is renewed for another 4 years!

Our NHLBI grant is renewed for another 4 years!
This grant involves a close collaboration with Dr. Susan Dutcher, Professor of Genetics, Cell Biology and Physiology, and Dr. Steven Brody, the Dorothy R. and Hubert C. Moog Professor of Pulmonary Medicine. We received a four-year, $3.14 million RO1 renewal grant from the National Heart, Lung, and Blood Institute (NHLBI) to study the “Regulation of Motile Cilia […]

Introducing our new rotation student, Jennysue Kasiah

Introducing our new rotation student, Jennysue Kasiah
Jennysue will be using cutting-edge imaging techniques, including expansion and superresolution microscopy, to study mechanisms that regulate centriole biogenesis and ciliogenesis in multiciliated cells. Welcome to the lab!

Welcome to our new postdoc Dr. Ewa Langner!

Welcome to our new postdoc Dr. Ewa Langner!
Ewa received a Bekker Programme postdoctoral fellowship from the Polish National Agency for Academic Exchange, and will be studying metabolic changes in Autosomal Dominant Polycystic Kidney Disease. Welcome to the lab!

Rashmi’s paper is published in eLife!

Rashmi’s paper is published in eLife!
Congratulations to first author Rashmi Nanjundappa, as well as former lab member Kyuhwan Shim, for their recent publication. This was a wonderful collaboration with Jadranka Loncarek (NIH) and her postdoc Dong Kong, as well as Steve Brody (Washington University) and Tim Stearns (Stanford). The study, “Regulation of Cilia Abundance in Multiciliated cells” can be found […]