Our paper about centriole appendages is published in Nature Comm.

Our paper about centriole appendages is published in Nature Comm.
This study was led by Jadranka Loncarek’s group (NIH). They used correlative super-resolution (STORM) microscopy and TEM tomography to characterize the organization of centriole distal appendages in various ciliated cells. The study, titled “High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy” is available online at Nature Communications.

NIH funded postdoc position focused on cystic kidney diseases

NIH funded postdoc position focused on cystic kidney diseases
An NIH (T32)-funded postdoctoral position is available in the Mahjoub Lab (Division of Nephrology, Washington University in St. Louis) to study the consequences of centrosomal defects during kidney development and homeostasis. Our group investigates how mutations in centrosomal and ciliary genes disrupt embryonic kidney development and cause renal Ciliopathies including Polycystic Kidney Disease and Nephronophthisis. […]

Moe presents our recent work at ASCB… and meets up with Erica!

Moe presents our recent work at ASCB… and meets up with Erica!
This was a reunion with the very first member of my lab, Erica Silva. She was an undergrad in Tim Stearns’ lab when I was a postdoc, and joined me when I moved to Washington University. She helped me setup the lab, start experiments, and train the first crew. We published the very first paper from the lab, […]

Our recent paper is highlighted in Nature Reviews – Nephrology.

Our recent paper is highlighted in Nature Reviews – Nephrology.
This study was a large collaboration between labs at UC Davis, Kansas University, University of Colorado and Washington University in St Louis. The project discovered that arginine auxotrophy is a key feature of autosomal dominant polycystic kidney disease (ADPKD). The results suggest that dietary arginine depletion, or targeting of the arginine metabolic pathway, may be a new therapeutic avenue in […]

The analysis of new mutations in RTTN is published.

The analysis of new mutations in RTTN is published.
This was a great collaboration with the labs of F. Sessions Cole III (Dept. of Pediatrics), Susan Dutcher (Genetics) and Thomas Ferkol (Pediatrics). The study titled “Functional characterization of biallelic RTTN variants identified in an infant with microcephaly, simplified gyral pattern, pontocerebellar hypoplasia, and seizures” can be found here.

Welcome to our visiting professor, Dr. Elif Firat-Karalar

Welcome to our visiting professor, Dr. Elif Firat-Karalar
Elif is Moe’s former lab-mate from Stanford, when they were both postdocs in Tim Stearns’ lab. She is now an Assistant Professor at Koc University in Istanbul (Turkey), working on deciphering the functions of centrioles satellites in mammalian cells. She will be spending a month with us here at WashU. You can visit here lab […]

Lai Kuan and Kyuhwan’s paper is published in JCB!

Lai Kuan and Kyuhwan’s paper is published in JCB!
Congratulations to co-first authors Lai Kuan Dionne and Kyuhwan Shim, as well as Tao Cheng, for their recent paper. It was a lot of hard work and the project took over 3 years to complete. This was a wonderful collaboration with Sanjay Jain (WU Nephrology) and his lab members Masato Hoshi and Amanda Knoten, as […]

Moe visits his old lab at SFU

Moe visits his old lab at SFU
It was very nostalgic to go back to Simon Fraser University, and walk the hallways again. Plus, it’s always great to see my old graduate mentor Lynne Quarmby.

Our paper on Nesprin1 is published in Current Biology

Our paper on Nesprin1 is published in Current Biology
This project was led by Dr. Didier Hodzic in the Opthalmology Department at Washington University. The study defined a novel function for the nuclear envelope-associated protein Nesprin1 at centriolar rootlets of various ciliated cell types. The manuscript was published in Current Biology and can be found here.