We are looking for postdoctoral fellows, graduate students and research assistants interested in the biology of microtubules, centrosomes and cilia. Our lab investigates how mutations in centrosomal and ciliary genes disrupt normal cell physiology, leading to human disease syndromes called “Ciliopathies”. These include cystic-fibrotic kidney diseases, and respiratory/airway defects such as Primary Cilia Dyskinesia. Multiple positions are available:
- A 4-year NIH-funded postdoctoral fellow: This project involves characterization of mechanisms involved in regulating centriole-cilia biogenesis and function in multiciliated cells. The trainee will use a primary airway stem-cell culture system, as well as mouse models of human disease genes, to investigate the biology of multiciliated cells in vitro and in vivo. Candidates will gain experience in cutting-edge imaging methods, including super-resolution and expansion microscopy, combined with proteomic and cell biology methods to determine the molecular mechanisms involved in centriologenesis and motile ciliogenesis. The ideal candidate will have excellent cell and developmental biology training, and experience with microcopy and/or biochemistry is strongly preferred.
- A 2-3-year NIH-funded position is available for a research assistant/technician. This position is ideal for recent graduates who would like to gain wet-lab experience. The candidate will work closely with a postdoctoral fellow on the projects described above.
Candidates should submit a short personal statement detailing their research interests and qualifications, and a CV (including a list of individuals who can provide references) by email to Moe Mahjoub (mmahjoub@wustl.edu).